Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response.

Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response.

Persistent infection of basal keratinocytes with high-risk human papillomavirus (hrHPV) may cause cancer. Keratinocytes are equipped with different pattern recognition receptors (PRRs) but hrHPV has developed ways to dampen their signals resulting in minimal inflammation and evasion of host immunity...

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Bibliographic Details
Main Authors: Rezaul Karim, Bart Tummers, Craig Meyers, Jennifer L Biryukov, Samina Alam, Claude Backendorf, Veena Jha, Rienk Offringa, Gert-Jan B van Ommen, Cornelis J M Melief, Daniele Guardavaccaro, Judith M Boer, Sjoerd H van der Burg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3662672?pdf=render

Internet

http://europepmc.org/articles/PMC3662672?pdf=render

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