Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication

Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication

Virus replication displays a large cell-to-cell heterogeneity; yet, not all sources of this variability are known. Here, we study the effect of defective interfering (DI) particle (DIP) co-infection on cell-to-cell variability in influenza A virus (IAV) replication. DIPs contain a large internal del...

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Bibliographic Details
Main Authors: Sascha Young Kupke, Lam-Ha Ly, Stefan Thomas Börno, Alexander Ruff, Bernd Timmermann, Martin Vingron, Stefan Haas, Udo Reichl
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Viruses
Subjects:
single-cell analysis
influenza a virus
cell-to-cell heterogeneity
defective interfering particles
single-cell rna sequencing
next-generation sequencing
Online Access:https://www.mdpi.com/1999-4915/12/1/71

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https://www.mdpi.com/1999-4915/12/1/71

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