Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer

Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer

Autophagy is dysregulated in cancer and might be involved in ovarian carcinogenesis. BECLIN-1, a protein that interacts with either BCL-2 or PI3k class III, plays a critical role in the regulation of both autophagy and cell death. Induction of autophagy is associated with the presence of vacuoles ch...

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Bibliographic Details
Main Authors: Guido Valente, Federica Morani, Giuseppina Nicotra, Nicola Fusco, Claudia Peracchio, Rossella Titone, Oscar Alabiso, Riccardo Arisio, Dyonissios Katsaros, Chiara Benedetto, Ciro Isidoro
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/462658

Internet

http://dx.doi.org/10.1155/2014/462658

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