Identification of microRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle.

BACKGROUND: Over the course of ageing there is a natural and progressive loss of skeletal muscle mass. The onset and progression of age-related muscle wasting is associated with an attenuated activation of Akt-mTOR signalling and muscle protein synthesis in response to anabolic stimuli such as resis...

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Bibliographic Details
Main Authors: Evelyn Zacharewicz, Paul Della Gatta, John Reynolds, Andrew Garnham, Tamsyn Crowley, Aaron P Russell, Séverine Lamon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4252069?pdf=render