RANK and RANK ligand expression in primary human osteosarcoma

RANK and RANK ligand expression in primary human osteosarcoma

Receptor activator of nuclear factor kappa-B ligand (RANKL) is an essential mediator of osteoclast formation, function and survival. In patients with solid tumor metastasis to the bone, targeting the bone microenvironment by inhibition of RANKL using denosumab, a fully human monoclonal antibody (mAb...

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Bibliographic Details
Main Authors: Daniel Branstetter, Kathy Rohrbach, Li-Ya Huang, Rosalia Soriano, Mark Tometsko, Michelle Blake, Allison P. Jacob, William C. Dougall
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Journal of Bone Oncology
Subjects:
RANK
RANKL
Human osteosarcoma
Antibodies
Protein expression
Immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137415300063

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http://www.sciencedirect.com/science/article/pii/S2212137415300063

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