Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours

Analysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific f...

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Main Authors: Suzanne S. Fei, Asia D. Mitchell, Michael B. Heskett, Cathy D. Vocke, Christopher J. Ricketts, Myron Peto, Nicholas J. Wang, Kemal Sönmez, W. Marston Linehan, Paul T. Spellman
Format: Article
Language:English
Published: Nature Publishing Group 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11588
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spelling doaj-18f99ca8ada94e7ca0e00a7053663d5b2021-05-11T11:21:17ZengNature Publishing GroupNature Communications2041-17232016-05-01711910.1038/ncomms11588Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumoursSuzanne S. Fei0Asia D. Mitchell1Michael B. Heskett2Cathy D. Vocke3Christopher J. Ricketts4Myron Peto5Nicholas J. Wang6Kemal Sönmez7W. Marston Linehan8Paul T. Spellman9Department of Molecular & Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityUrologic Oncology Branch, Center for Cancer Research, National Cancer InstituteUrologic Oncology Branch, Center for Cancer Research, National Cancer InstituteDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityDepartment of Biomedical Engineering, Oregon Health & Science UniversityDepartment of Biomedical Engineering, Oregon Health & Science UniversityUrologic Oncology Branch, Center for Cancer Research, National Cancer InstituteDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityAnalysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific factors influence tumour formation.https://doi.org/10.1038/ncomms11588
collection DOAJ
language English
format Article
sources DOAJ
author Suzanne S. Fei
Asia D. Mitchell
Michael B. Heskett
Cathy D. Vocke
Christopher J. Ricketts
Myron Peto
Nicholas J. Wang
Kemal Sönmez
W. Marston Linehan
Paul T. Spellman
spellingShingle Suzanne S. Fei
Asia D. Mitchell
Michael B. Heskett
Cathy D. Vocke
Christopher J. Ricketts
Myron Peto
Nicholas J. Wang
Kemal Sönmez
W. Marston Linehan
Paul T. Spellman
Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
Nature Communications
author_facet Suzanne S. Fei
Asia D. Mitchell
Michael B. Heskett
Cathy D. Vocke
Christopher J. Ricketts
Myron Peto
Nicholas J. Wang
Kemal Sönmez
W. Marston Linehan
Paul T. Spellman
author_sort Suzanne S. Fei
title Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_short Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_full Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_fullStr Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_full_unstemmed Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_sort patient-specific factors influence somatic variation patterns in von hippel–lindau disease renal tumours
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-05-01
description Analysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific factors influence tumour formation.
url https://doi.org/10.1038/ncomms11588
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