Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours

Analysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific f...

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Main Authors:	Suzanne S. Fei, Asia D. Mitchell, Michael B. Heskett, Cathy D. Vocke, Christopher J. Ricketts, Myron Peto, Nicholas J. Wang, Kemal Sönmez, W. Marston Linehan, Paul T. Spellman
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11588

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spelling	doaj-18f99ca8ada94e7ca0e00a7053663d5b2021-05-11T11:21:17ZengNature Publishing GroupNature Communications2041-17232016-05-01711910.1038/ncomms11588Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumoursSuzanne S. Fei0Asia D. Mitchell1Michael B. Heskett2Cathy D. Vocke3Christopher J. Ricketts4Myron Peto5Nicholas J. Wang6Kemal Sönmez7W. Marston Linehan8Paul T. Spellman9Department of Molecular & Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityUrologic Oncology Branch, Center for Cancer Research, National Cancer InstituteUrologic Oncology Branch, Center for Cancer Research, National Cancer InstituteDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityDepartment of Biomedical Engineering, Oregon Health & Science UniversityDepartment of Biomedical Engineering, Oregon Health & Science UniversityUrologic Oncology Branch, Center for Cancer Research, National Cancer InstituteDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityAnalysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific factors influence tumour formation.https://doi.org/10.1038/ncomms11588
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Suzanne S. Fei Asia D. Mitchell Michael B. Heskett Cathy D. Vocke Christopher J. Ricketts Myron Peto Nicholas J. Wang Kemal Sönmez W. Marston Linehan Paul T. Spellman
spellingShingle	Suzanne S. Fei Asia D. Mitchell Michael B. Heskett Cathy D. Vocke Christopher J. Ricketts Myron Peto Nicholas J. Wang Kemal Sönmez W. Marston Linehan Paul T. Spellman Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours Nature Communications
author_facet	Suzanne S. Fei Asia D. Mitchell Michael B. Heskett Cathy D. Vocke Christopher J. Ricketts Myron Peto Nicholas J. Wang Kemal Sönmez W. Marston Linehan Paul T. Spellman
author_sort	Suzanne S. Fei
title	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_short	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_full	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_fullStr	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_full_unstemmed	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_sort	patient-specific factors influence somatic variation patterns in von hippel–lindau disease renal tumours
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-05-01
description	Analysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific factors influence tumour formation.
url	https://doi.org/10.1038/ncomms11588
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Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours

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