Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
Analysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific f...
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2016-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms11588 |
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doaj-18f99ca8ada94e7ca0e00a7053663d5b2021-05-11T11:21:17ZengNature Publishing GroupNature Communications2041-17232016-05-01711910.1038/ncomms11588Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumoursSuzanne S. Fei0Asia D. Mitchell1Michael B. Heskett2Cathy D. Vocke3Christopher J. Ricketts4Myron Peto5Nicholas J. Wang6Kemal Sönmez7W. Marston Linehan8Paul T. Spellman9Department of Molecular & Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityUrologic Oncology Branch, Center for Cancer Research, National Cancer InstituteUrologic Oncology Branch, Center for Cancer Research, National Cancer InstituteDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityDepartment of Biomedical Engineering, Oregon Health & Science UniversityDepartment of Biomedical Engineering, Oregon Health & Science UniversityUrologic Oncology Branch, Center for Cancer Research, National Cancer InstituteDepartment of Molecular & Medical Genetics, Oregon Health & Science UniversityAnalysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific factors influence tumour formation.https://doi.org/10.1038/ncomms11588 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suzanne S. Fei Asia D. Mitchell Michael B. Heskett Cathy D. Vocke Christopher J. Ricketts Myron Peto Nicholas J. Wang Kemal Sönmez W. Marston Linehan Paul T. Spellman |
spellingShingle |
Suzanne S. Fei Asia D. Mitchell Michael B. Heskett Cathy D. Vocke Christopher J. Ricketts Myron Peto Nicholas J. Wang Kemal Sönmez W. Marston Linehan Paul T. Spellman Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours Nature Communications |
author_facet |
Suzanne S. Fei Asia D. Mitchell Michael B. Heskett Cathy D. Vocke Christopher J. Ricketts Myron Peto Nicholas J. Wang Kemal Sönmez W. Marston Linehan Paul T. Spellman |
author_sort |
Suzanne S. Fei |
title |
Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours |
title_short |
Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours |
title_full |
Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours |
title_fullStr |
Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours |
title_full_unstemmed |
Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours |
title_sort |
patient-specific factors influence somatic variation patterns in von hippel–lindau disease renal tumours |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-05-01 |
description |
Analysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific factors influence tumour formation. |
url |
https://doi.org/10.1038/ncomms11588 |
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