3′-UTR Shortening Contributes to Subtype-Specific Cancer Growth by Breaking Stable ceRNA Crosstalk of Housekeeping Genes

3′-UTR Shortening Contributes to Subtype-Specific Cancer Growth by Breaking Stable ceRNA Crosstalk of Housekeeping Genes

Shortening of 3′UTRs (3′US) through alternative polyadenylation is a post-transcriptional mechanism that regulates the expression of hundreds of genes in human cancers. In breast cancer, different subtypes of tumor samples, such as estrogen receptor positive and negative (ER+ and ER–), are character...

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Bibliographic Details
Main Authors: Zhenjiang Fan, Soyeon Kim, Yulong Bai, Brenda Diergaarde, Hyun Jung Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
competing-endogenous RNA
housekeeping genes
breast cancer subtypes
RNA regulation
alternative polyadenylation (APA)
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00334/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00334/full

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