A mathematical model explains saturating axon guidance responses to molecular gradients

Correct wiring is crucial for the proper functioning of the nervous system. Molecular gradients provide critical signals to guide growth cones, which are the motile tips of developing axons, to their targets. However, in vitro, growth cones trace highly stochastic trajectories, and exactly how molec...

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Bibliographic Details
Main Authors: Huyen Nguyen, Peter Dayan, Zac Pujic, Justin Cooper-White, Geoffrey J Goodhill
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/12248