Frozen cord blood hematopoietic stem cells differentiate into higher numbers of functional natural killer cells in vitro than mobilized hematopoietic stem cells or freshly isolated cord blood hematopoietic stem cells.

Frozen cord blood hematopoietic stem cells differentiate into higher numbers of functional natural killer cells in vitro than mobilized hematopoietic stem cells or freshly isolated cord blood hematopoietic stem cells.

Adoptive natural killer (NK) cell therapy relies on the acquisition of large numbers of NK cells that are cytotoxic but not exhausted. NK cell differentiation from hematopoietic stem cells (HSC) has become an alluring option for NK cell therapy, with umbilical cord blood (UCB) and mobilized peripher...

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Bibliographic Details
Main Authors: Martha Luevano, Anna Domogala, Michael Blundell, Nicola Jackson, Isabela Pedroza-Pacheco, Sophie Derniame, Michelle Escobedo-Cousin, Sergio Querol, Adrian Thrasher, Alejandro Madrigal, Aurore Saudemont
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3906137?pdf=render

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http://europepmc.org/articles/PMC3906137?pdf=render

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