Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2

Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2

Abstract Background Cerebral hypoperfusion is a pivotal risk factor for vascular dementia (VD), for which effective therapy remains inadequate. Persistent inflammatory responses and excessive chemotaxis of microglia/macrophages in the brain may accelerate the progression of VD. Endocannabinoids are...

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Bibliographic Details
Main Authors: Xian-Qin Luo, Ao Li, Xue Yang, Xiao Xiao, Rong Hu, Tian-Wen Wang, Xiao-Yun Dou, Da-Jian Yang, Zhi Dong
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Chinese Medicine
Subjects:
Paeoniflorin
Cannabinoid receptor 2
Vascular dementia
Neuroprotection
Online Access:http://link.springer.com/article/10.1186/s13020-018-0173-1

Internet

http://link.springer.com/article/10.1186/s13020-018-0173-1

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