TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation

TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation

Wnt/β-Catenin signaling is involved in embryonic development, regeneration, and cellular differentiation and is responsible for cancer stemness maintenance. The HSP90 molecular chaperone TRAP1 is upregulated in 60–70% of human colorectal carcinomas (CRCs) and favors stem cells maintenance, modulatin...

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Bibliographic Details
Main Authors: Giacomo Lettini, Valentina Condelli, Michele Pietrafesa, Fabiana Crispo, Pietro Zoppoli, Francesca Maddalena, Ilaria Laurenzana, Alessandro Sgambato, Franca Esposito, Matteo Landriscina
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
molecular chaperone
TRAP1
Wnt signaling
cancer stem cell
colon cancer
stemness
Online Access:https://www.mdpi.com/1422-0067/21/20/7526

Internet

https://www.mdpi.com/1422-0067/21/20/7526

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