Batch correction evaluation framework using a-priori gene-gene associations: applied to the GTEx dataset

Batch correction evaluation framework using a-priori gene-gene associations: applied to the GTEx dataset

Abstract Background Correcting a heterogeneous dataset that presents artefacts from several confounders is often an essential bioinformatics task. Attempting to remove these batch effects will result in some biologically meaningful signals being lost. Thus, a central challenge is assessing if the re...

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Bibliographic Details
Main Authors: Judith Somekh, Shai S Shen-Orr, Isaac S Kohane
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Bioinformatics
Subjects:
Batch correction
Batch effect
Gene expression
ComBat
Principal component analysis
GTEx
Online Access:http://link.springer.com/article/10.1186/s12859-019-2855-9

Internet

http://link.springer.com/article/10.1186/s12859-019-2855-9

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