Optineurin defects cause TDP43-pathology with autophagic vacuolar formation

Optineurin defects cause TDP43-pathology with autophagic vacuolar formation

We previously showed that optineurin (OPTN) mutations lead to the development of amyotrophic lateral sclerosis. The association between OPTN mutations and the pathogenesis of amyotrophic lateral sclerosis remains unclear. To investigate the mechanism underlying its pathogenesis, we generated Optn kn...

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Bibliographic Details
Main Authors: Takashi Kurashige, Masahito Kuramochi, Ryosuke Ohsawa, Yui Yamashita, Go Shioi, Hiroyuki Morino, Masaki Kamada, Takashi Ayaki, Hidefumi Ito, Yusuke Sotomaru, Hirofumi Maruyama, Hideshi Kawakami
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Optineurin
TDP-43
Charged multivesicular body protein 2b
Granulovacuolar degenerations
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304903

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http://www.sciencedirect.com/science/article/pii/S0969996120304903

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