Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome

Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome

Inactivating mutations in the Methyl-CpG Binding Protein 2 (MECP2) gene are the main cause of Rett syndrome (RTT). Despite extensive research into MECP2 function, no treatments for RTT are currently available. Here, we used an evolutionary genomics approach to construct an unbiased MECP2 gene networ...

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Bibliographic Details
Main Authors: Irene Unterman, Idit Bloch, Simona Cazacu, Gila Kazimirsky, Bruria Ben-Zeev, Benjamin P Berman, Chaya Brodie, Yuval Tabach
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
rett syndrome
phylogenetic profiling
comparative genomics
pacritinib
erythropoietin
dimethyl fumarate
Online Access:https://elifesciences.org/articles/67085

Internet

https://elifesciences.org/articles/67085

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