Immunization of rabbits with highly purified, soluble, trimeric human immunodeficiency virus type 1 envelope glycoprotein induces a vigorous B cell response and broadly cross-reactive neutralization.

Immunization of rabbits with highly purified, soluble, trimeric human immunodeficiency virus type 1 envelope glycoprotein induces a vigorous B cell response and broadly cross-reactive neutralization.

Previously we described induction of cross-reactive HIV-1 neutralizing antibody responses in rabbits using a soluble HIV-1 gp140 envelope glycoprotein (Env) in an adjuvant containing monophosphoryl lipid A (MPL) and QS21 (AS02A). Here, we compared different forms of the same HIV-1 strain R2 Env for...

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Bibliographic Details
Main Authors: Gerald V Quinnan, Olusegun Onabajo, Pengfei Zhang, Lianying Yan, Joseph J Mattapallil, Zhiqiang Zhang, Ming Dong, Min Lu, David Montefiori, Celia LaBranche, Christopher C Broder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4028264?pdf=render

Internet

http://europepmc.org/articles/PMC4028264?pdf=render

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