Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent.

Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent.

Plasmodium falciparum infection can cause microvascular dysfunction, cerebral encephalopathy and death if untreated. We have previously shown that high concentrations of free heme, and C-X-C motif chemokine 10 (CXCL10) in sera of malaria patients induce apoptosis in microvascular endothelial and neu...

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Bibliographic Details
Main Authors: Carmen M Dickinson-Copeland, Nana O Wilson, Mingli Liu, Adel Driss, Hassana Salifu, Andrew A Adjei, Michael Wilson, Ben Gyan, Daniel Oduro, Kingsley Badu, Felix Botchway, Winston Anderson, Vincent Bond, Methode Bacanamwo, Shailesh Singh, Jonathan K Stiles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4640861?pdf=render

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http://europepmc.org/articles/PMC4640861?pdf=render

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