M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis

M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis

Abstract Background Macrophages may present two distinct phenotypes indicated as M1 and M2 under different stimuli. M1 and M2 macrophages have divergent functions that range from enhancement of inflammation for M1 to tissue repair and remodeling for M2 macrophages. The objective of this study was to...

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Bibliographic Details
Main Authors: Alexandre Wagner Silva de Souza, Mirjan van Timmeren, Jan-Stephan Sanders, Coen Stegeman, Peter Heeringa, Cees G. M. Kallenberg, Johanna Westra
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Arthritis Research & Therapy
Subjects:
Granulomatosis with polyangiitis
Macrophages
granuloma
Antineutrophil cytoplasmic antibodies
T cells
Online Access:http://link.springer.com/article/10.1186/s13075-017-1310-4

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http://link.springer.com/article/10.1186/s13075-017-1310-4

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