AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage

AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage

Enhanced vascular permeability in the lungs can lead to pulmonary edema, impaired gas exchange, and ultimately respiratory failure. While oxygen delivery, mechanical ventilation, and pressure-reducing medications help alleviate these symptoms, they do not treat the underlying disease. Mechanical act...

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Bibliographic Details
Main Authors: Juan Li, Amy M. Wen, Ratnakar Potla, Ezekiel Benshirim, Ariel Seebarran, Maximilian A. Benz, Olivier Y. F. Henry, Benjamin D. Matthews, Rachelle Prantil-Baun, Sarah E. Gilpin, Oren Levy, Donald E. Ingber
Format: Article
Language:English
Published: AIP Publishing LLC 2019-12-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/1.5122967

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http://dx.doi.org/10.1063/1.5122967

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