Characterization of the antigen-specific CD4+ T cell response induced by prime-boost strategies with CAF01 and CpG adjuvants administered by the intranasal and subcutaneous routes

Characterization of the antigen-specific CD4+ T cell response induced by prime-boost strategies with CAF01 and CpG adjuvants administered by the intranasal and subcutaneous routes

The design of heterologous prime-boost vaccine combinations that optimally shape the immune response is of critical importance for the development of next generation vaccines. Here we tested different prime-boost combinations using the tuberculosis vaccine antigen H56 with CAF01 or CpG ODN 1821 adj...

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Bibliographic Details
Main Authors: Annalisa eCiabattini, Gennaro eProta, Dennis eChristensen, Peter eAndersen, Gianni ePozzi, Donata eMedaglini
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Immunology
Subjects:
Chemokines
lungs
CpG DNA
MHC class II tetramers
Prime-boost strategies
CD4+ T cell priming
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00430/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00430/full

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