CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity
Abstract CRISPR-based nucleic acid detection methods are reported to facilitate rapid and sensitive DNA detection. However, precise DNA detection at the single-base resolution and its wide applications including high-fidelity SNP genotyping remain to be explored. Here we develop a Cas12b-mediated DN...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-07-01
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| Series: | Genome Biology |
| Online Access: | http://link.springer.com/article/10.1186/s13059-019-1742-z |