Native Mass Spectrometry in Fragment-Based Drug Discovery

Native Mass Spectrometry in Fragment-Based Drug Discovery

The advent of native mass spectrometry (MS) in 1990 led to the development of new mass spectrometry instrumentation and methodologies for the analysis of noncovalent protein–ligand complexes. Native MS has matured to become a fast, simple, highly sensitive and automatable technique with well-establi...

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Bibliographic Details
Main Authors: Liliana Pedro, Ronald J. Quinn
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Molecules
Subjects:
native MS
fragment-based drug discovery
noncovalent interaction
protein-ligand complex
fragment-based screening
binding stoichiometry
binding specificity
binding affinity
structure-activity relationship
Online Access:http://www.mdpi.com/1420-3049/21/8/984

Internet

http://www.mdpi.com/1420-3049/21/8/984

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