A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones

A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.

Bibliographic Details
Main Authors:	Rositca D. Nikolova, Nevena I. Petkova, Eleonora D. Ilieva
Format:	Article
Language:	English
Published:	MDPI AG 2012-04-01
Series:	Molecules
Subjects:	pyrrolidine-2,5-dione pyrrolidine 3-substituted coumarins 2-oxo-2<em>Н</em>-1-benzopyrane Michael addition reaction rearrangement Nef reaction
Online Access:	http://www.mdpi.com/1420-3049/17/5/4936

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spelling	doaj-192a397890f042b6943deaa57b376ea42020-11-24T21:22:18ZengMDPI AGMolecules1420-30492012-04-011754936494910.3390/molecules17054936A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-dionesRositca D. NikolovaNevena I. PetkovaEleonora D. IlievaA newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.http://www.mdpi.com/1420-3049/17/5/4936pyrrolidine-2,5-dionepyrrolidine3-substituted coumarins2-oxo-2<em>Н</em>-1-benzopyraneMichael addition reactionrearrangementNef reaction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rositca D. Nikolova Nevena I. Petkova Eleonora D. Ilieva
spellingShingle	Rositca D. Nikolova Nevena I. Petkova Eleonora D. Ilieva A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones Molecules pyrrolidine-2,5-dione pyrrolidine 3-substituted coumarins 2-oxo-2<em>Н</em>-1-benzopyrane Michael addition reaction rearrangement Nef reaction
author_facet	Rositca D. Nikolova Nevena I. Petkova Eleonora D. Ilieva
author_sort	Rositca D. Nikolova
title	A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_short	A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_full	A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_fullStr	A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_full_unstemmed	A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_sort	new and efficient method for the synthesis of 3,4-disubstituted pyrrolidine-2,5-diones
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2012-04-01
description	A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.
topic	pyrrolidine-2,5-dione pyrrolidine 3-substituted coumarins 2-oxo-2<em>Н</em>-1-benzopyrane Michael addition reaction rearrangement Nef reaction
url	http://www.mdpi.com/1420-3049/17/5/4936
work_keys_str_mv	AT rositcadnikolova anewandefficientmethodforthesynthesisof34disubstitutedpyrrolidine25diones AT nevenaipetkova anewandefficientmethodforthesynthesisof34disubstitutedpyrrolidine25diones AT eleonoradilieva anewandefficientmethodforthesynthesisof34disubstitutedpyrrolidine25diones AT rositcadnikolova newandefficientmethodforthesynthesisof34disubstitutedpyrrolidine25diones AT nevenaipetkova newandefficientmethodforthesynthesisof34disubstitutedpyrrolidine25diones AT eleonoradilieva newandefficientmethodforthesynthesisof34disubstitutedpyrrolidine25diones
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A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones

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