β-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibition of renal fibroblast activation and fibrosis

β-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibition of renal fibroblast activation and fibrosis

Renal fibrosis is a hallmark feature of chronic kidney disease, which is reflected by proliferation and migration of interstitial fibroblasts and extracellular matrix (ECM) accumulation. β-Aminoisobutyric acid (BAIBA) is recently demonstrated to exert a protective role from metabolic diseases. Howev...

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Bibliographic Details
Main Authors: Huijuan Wang, Jun Qian, Xiufen Zhao, Changing Xing, Bin Sun
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Journal of Pharmacological Sciences
Subjects:
β-Aminoisobutyric acid
Angiotensin II
Extracellular matrix
Interleukin-17
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317300038

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http://www.sciencedirect.com/science/article/pii/S1347861317300038

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