Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection.

Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection.

The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic HIV-1 efficiently enters tissue-derived memory CD4...

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Bibliographic Details
Main Authors: Feng Hsiao, Julie Frouard, Andrea Gramatica, Guorui Xie, Sushama Telwatte, Guinevere Q Lee, Pavitra Roychoudhury, Roland Schwarzer, Xiaoyu Luo, Steven A Yukl, Sulggi Lee, Rebecca Hoh, Steven G Deeks, R Brad Jones, Marielle Cavrois, Warner C Greene, Nadia R Roan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008450

Internet

https://doi.org/10.1371/journal.ppat.1008450

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