Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells

Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells

Abstract Background Chronic exposure of pancreatic β-cells to excess free fatty acids is thought to contribute to type 2 diabetes pathogenesis in obesity by impairing β-cell function and even leading to apoptosis. In β-cells, lipid droplet-associated protein perilipin 5 (PLIN5) has been shown to enh...

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Bibliographic Details
Main Authors: Yunxia Zhu, Xiaoyan Zhang, Li Zhang, Mingliang Zhang, Ling Li, Deng Luo, Yuan Zhong
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Nutrition & Metabolism
Subjects:
Perilipin 5
Lipotoxicity
β-Cell function
Endoplasmic reticulum stress
Fatty acid oxidation
Online Access:http://link.springer.com/article/10.1186/s12986-019-0375-2

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http://link.springer.com/article/10.1186/s12986-019-0375-2

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