Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis

Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis

Oxidative stress is the main factor responsible for the induction of diabetic renal fibrosis. Thus, improving the state of oxidative stress can effectively prevent the further deterioration of diabetic nephropathy (DN). Previous research has shown that formononetin (FMN), a flavonoid with significan...

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Bibliographic Details
Main Authors: Kai Zhuang, Xiyu Jiang, Renbin Liu, Cunsi Ye, Yumei Wang, Yunhan Wang, Shijian Quan, Heqing Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
formononetin
diabetic nephropathy
renal fibrosis
oxidative stress
Sirt1/Nrf2/ARE signaling pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.616378/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.616378/full

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