H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner

H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner

Abstract Background Evidence of global heterochromatin decay and aberrant gene expression in models of physiological and premature ageing have long supported the “heterochromatin loss theory of ageing”, which proposes that ageing is aetiologically linked to, and accompanied by, a progressive, genera...

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Bibliographic Details
Main Authors: Abigail R. R. Guillermo, Karolina Chocian, Gavriil Gavriilidis, Julien Vandamme, Anna Elisabetta Salcini, Jane Mellor, Alison Woollard
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Biology
Subjects:
Ageing
Lifespan
Healthspan
C. elegans
Chromatin
Histone demethylase
Online Access:https://doi.org/10.1186/s12915-021-00984-8

Internet

https://doi.org/10.1186/s12915-021-00984-8

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