Tumor bioengineering using a transglutaminase crosslinked hydrogel.

Development of a physiologically relevant 3D model system for cancer research and drug development is a current challenge. We have adopted a 3D culture system based on a transglutaminase-crosslinked gelatin gel (Col-Tgel) to mimic the tumor 3D microenvironment. The system has several unique advantag...

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Bibliographic Details
Main Authors: Josephine Y Fang, Shih-Jye Tan, Zhi Yang, Charisse Tayag, Bo Han
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4136878?pdf=render