Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-Primase Complex

Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-Primase Complex

Promising new inhibitors that target the viral helicase-primase complex have been reported to block replication of herpes simplex and varicella-zoster viruses, but they have no activity against human cytomegalovirus (HCMV), another herpesvirus. The HCMV helicase-primase complex (pUL105-pUL102-pUL70)...

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Bibliographic Details
Main Authors: Gaetan Ligat, Sandra Da Re, Sophie Alain, Sébastien Hantz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Microbiology
Subjects:
human cytomegalovirus
helicase-primase
molecular modeling
mutagenesis
antiviral drugs
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02483/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02483/full

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