Resistance-Nodulation-Division Efflux Pump, LexABC, Contributes to Self-Resistance of the Phenazine Di-N-Oxide Natural Product Myxin in Lysobacter antibioticus

Resistance-Nodulation-Division Efflux Pump, LexABC, Contributes to Self-Resistance of the Phenazine Di-N-Oxide Natural Product Myxin in Lysobacter antibioticus

Antibiotic-producing microorganisms have developed several self-resistance mechanisms to protect them from autotoxicity. Transporters belonging to the resistance- nodulation-division (RND) superfamily commonly confer multidrug resistance in Gram-negative bacteria. Phenazines are heterocyclic, nitrog...

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Bibliographic Details
Main Authors: Yangyang Zhao, Jiayu Liu, Tianping Jiang, Rongxian Hou, Gaoge Xu, Huiyong Xu, Fengquan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Microbiology
Subjects:
phenazine
RND pump
antibiotic resistance
LysR-type regulator
Lysobacter antibioticus
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.618513/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.618513/full

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