Deficient Incorporation of Rabies Virus Glycoprotein into Virions Enhances Virus-Induced Immune Evasion and Viral Pathogenicity

Deficient Incorporation of Rabies Virus Glycoprotein into Virions Enhances Virus-Induced Immune Evasion and Viral Pathogenicity

Previous studies have shown that wild-type (wt) rabies virus (RABV) evades the host immune response by restricting expression of glycoprotein (G), which blocks activation of dendritic cells (DCs) and induces production of virus-neutralizing antibodies (VNAs). In the present study, wt RABVs not only...

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Bibliographic Details
Main Authors: Chunfu Li, Hongliang Zhang, Lina Ji, Xiao Wang, Yongjun Wen, Guangpeng Li, Zhen F. Fu, Yang Yang
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Viruses
Subjects:
rabies virus
immune evasion
glycoprotein incorporation
laboratory-attenuated rabies virus
wild-type rabies virus
dendritic cell activation
membrane fusion
Online Access:http://www.mdpi.com/1999-4915/11/3/218

Internet

http://www.mdpi.com/1999-4915/11/3/218

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