Direct Crosstalk Between O-GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy

Direct Crosstalk Between O-GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy

The formation of intraneuronal fibrillar inclusions of tau protein is associated with several neurodegenerative diseases referred to as tauopathies including Alzheimer's disease (AD). A common feature of these pathologies is hyperphosphorylation of tau, the main component of fibrillar assemblie...

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Bibliographic Details
Main Authors: Gwendoline Bourré, François-Xavier Cantrelle, Amina Kamah, Béatrice Chambraud, Isabelle Landrieu, Caroline Smet-Nocca
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Endocrinology
Subjects:
Tau protein
phosphorylation
O-GlcNAcylation
crosstalk
NMR spectroscopy
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00595/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00595/full

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