Long-Term Ibrutinib Therapy Reverses CD8+ T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia

Long-Term Ibrutinib Therapy Reverses CD8+ T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia

Chronic Lymphocytic Leukaemia (CLL) is associated with immune suppression and susceptibility to infection. CD8+ T cell numbers are increased and demonstrate elevated expression of PD-1 and impaired function. The mechanisms driving these features of exhaustion are uncertain but are likely to include...

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Bibliographic Details
Main Authors: Helen M. Parry, Nikhil Mirajkar, Natasha Cutmore, Jianmin Zuo, Heather Long, Marwan Kwok, Ceri Oldrieve, Chris Hudson, Tatjana Stankovic, Shankara Paneesha, Melanie Kelly, Jusnara Begum, Tina McSkeane, Guy Pratt, Paul Moss
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
ibrutinib
chronic lymphocytic leukaemia (CLL)
herpes viruses
exhaustion
EBV—epstein-barr virus
CD8 T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02832/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02832/full

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