Gentamicin Affects the Bioenergetics of Isolated Mitochondria and Collapses the Mitochondrial Membrane Potential in Cochlear Sensory Hair Cells

Gentamicin Affects the Bioenergetics of Isolated Mitochondria and Collapses the Mitochondrial Membrane Potential in Cochlear Sensory Hair Cells

Aminoglycoside antibiotics are widely prescribed to treat a variety of serious bacterial infections. They are extremely useful clinical tools, but have adverse side effects such as oto- and nephrotoxicity. Once inside a cell they are thought to cause mitochondrial dysfunction, subsequently leading t...

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Bibliographic Details
Main Authors: Molly O’Reilly, Luke Young, Nerissa K. Kirkwood, Guy P. Richardson, Corné J. Kros, Anthony L. Moore
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
aminoglycoside
gentamicin
mitochondria
bioenergetics
hair cell
ototoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00416/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00416/full

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