Depletion of tumor associated macrophages slows the growth of chemically-induced mouse lung adenocarcinomas

Depletion of tumor associated macrophages slows the growth of chemically-induced mouse lung adenocarcinomas

Chronic inflammation is a risk factor for lung cancer, and low dose aspirin intake reduces lung cancer risk. However, the roles that specific inflammatory cells and their products play in lung carcinogenesis have yet to be fully elucidated. In mice, alveolar macrophage numbers increase as lung tum...

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Bibliographic Details
Main Authors: Jason M. Fritz, Meredith A. Tennis, David J. Orlicky, Hao eYin, Cynthia eJu, Elizabeth F. Redente, Kevin S. Choo, Taylor A. Staab, Ronald J. Bouchard, Daniel T. Merrick, Alvin M. Malkinson, Lori` D. Dwyer-Nield
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Immunology
Subjects:
Tumor Microenvironment
lung cancer
mouse models
macrohpage depletion
macrophage programming
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00587/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00587/full

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