Synthesis, Evaluation for Cytotoxicity and Molecular Docking Studies of Benzo[c]furan-Chalcones for Potential to Inhibit Tubulin Polymerization and/or EGFR-Tyrosine Kinase Phosphorylation

Synthesis, Evaluation for Cytotoxicity and Molecular Docking Studies of Benzo[c]furan-Chalcones for Potential to Inhibit Tubulin Polymerization and/or EGFR-Tyrosine Kinase Phosphorylation

A series of 2-arylbenzo[c]furan-chalcone hybrids 3a–y have been synthesized and evaluated for antiproliferative effects against the human breast cancer (MCF-7) cell line and for its potential to induce apoptosis and also to inhibit tubulin polymerization and/or epidermal growth factor rece...

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Bibliographic Details
Main Authors: Malose J. Mphahlele, Marole M. Maluleka, Nishal Parbhoo, Sibusiso T. Malindisa
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
benzofuran-chalcones
cytotoxicity
apoptosis
tubulin
EGFR
molecular docking
Online Access:http://www.mdpi.com/1422-0067/19/9/2552

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http://www.mdpi.com/1422-0067/19/9/2552

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