Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk

Summary: Autophagy is a homeostatic cellular process involved in the degradation of long-lived or damaged cellular components. The role of autophagy in adipogenesis is well recognized, but its role in mature adipocyte function is largely unknown. We show that the autophagy proteins Atg3 and Atg16L1...

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Bibliographic Details
Main Authors: Jinjin Cai, Karla M. Pires, Maroua Ferhat, Bhagirath Chaurasia, Márcio A. Buffolo, Rana Smalling, Ashot Sargsyan, Donald L. Atkinson, Scott A. Summers, Timothy E. Graham, Sihem Boudina
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316292