Experimental Design to Evaluate Directed Adaptive Mutation in Mammalian Cells

BackgroundWe describe the experimental design for a methodological approach to determine whether directed adaptive mutation occurs in mammalian cells. Identification of directed adaptive mutation would have profound practical significance for a wide variety of biomedical prob...

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Bibliographic Details
Main Authors: Bordonaro, Michael, Chiaro, Christopher R, May, Tobias
Format: Article
Language:English
Published: JMIR Publications 2014-12-01
Series:JMIR Research Protocols
Online Access:http://www.researchprotocols.org/2014/4/e74/