Identification of a bilirubin receptor that may mediate a component of cholestatic itch

Various pathologic conditions result in jaundice, a yellowing of the skin due to a buildup of bilirubin. Patients with jaundice commonly report experiencing an intense non-histaminergic itch. Despite this association, the pruritogenic capacity of bilirubin itself has not been described, and no bilir...

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Bibliographic Details
Main Authors: James Meixiong, Chirag Vasavda, Dustin Green, Qin Zheng, Lijun Qi, Shawn G Kwatra, James P Hamilton, Solomon H Snyder, Xinzhong Dong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/44116