Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

Summary: SORL1/SORLA is a sorting receptor involved in retromer-related endosomal traffic and an Alzheimer’s disease (AD) risk gene. Using CRISPR-Cas9, we deplete SORL1 in hiPSCs to ask if loss of SORL1 contributes to AD pathogenesis by endosome dysfunction. SORL1-deficient hiPSC neurons show early...

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Bibliographic Details
Main Authors: Allison Knupp, Swati Mishra, Refugio Martinez, Jacquelyn E. Braggin, Marcell Szabo, Chizuru Kinoshita, Dale W. Hailey, Scott A. Small, Suman Jayadev, Jessica E. Young
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
Alzheimer's disease
human induced pluripotent stem cells
SORL1
early endosomes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306963

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http://www.sciencedirect.com/science/article/pii/S2211124720306963

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