PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease

Parkinson's disease (PD) is one of the most frequent neurodegenerative disease caused by the preferential, progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra (SN) pars compacta. PD is characterized by a multifaceted pathological process involving protein misfoldin...

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Bibliographic Details
Main Authors: Olga Corti, Francois Mouton-Liger, Maxime Jacoupy, Jean-Christophe Corvol
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson disease
Pink1/Parkin
mitochondrial quality control
neuronal death
mitochondrial stress
neuroinflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00120/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00120/full

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