Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model.

Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model.

The long-term fate of stem cells after intramyocardial delivery is unknown. We used noninvasive, repetitive PET/CT imaging with [(18)F]FEAU to monitor the long-term (up to 5 months) spatial-temporal dynamics of MSCs retrovirally transduced with the sr39HSV1-tk gene (sr39HSV1-tk-MSC) and implanted in...

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Main Authors: Emerson C Perin, Mei Tian, Frank C Marini, Guilherme V Silva, Yi Zheng, Fred Baimbridge, Xin Quan, Marlos R Fernandes, Amir Gahremanpour, Daniel Young, Vincenzo Paolillo, Uday Mukhopadhyay, Agatha T Borne, Rajesh Uthamanthil, David Brammer, James Jackson, William K Decker, Amer M Najjar, Michael W Thomas, Andrei Volgin, Brian Rabinovich, Suren Soghomonyan, Hwan-Jeong Jeong, Jesse M Rios, David Steiner, Simon Robinson, Osama Mawlawi, Tinsu Pan, Jason Stafford, Vikas Kundra, Chun Li, Mian M Alauddin, James T Willerson, Elizabeth Shpall, Juri G Gelovani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3164664?pdf=render

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http://europepmc.org/articles/PMC3164664?pdf=render

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