TFAM-deficient mouse skin fibroblasts – an ex vivo model of mitochondrial dysfunction

TFAM-deficient mouse skin fibroblasts – an ex vivo model of mitochondrial dysfunction

Mitochondrial dysfunction associates with several pathological processes and contributes to chronic inflammatory and ageing-related diseases. Mitochondrial transcription factor A (TFAM) plays a critical role in maintaining mtDNA integrity and function. Taking advantage of Tfamfl/fl UBC-Cre/ERT2+/+ m...

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Bibliographic Details
Main Authors: Manuel J. Del Rey, Carolina Meroño, Cristina Municio, Alicia Usategui, María Mittelbrunn, Inés García-Consuegra, Gabriel Criado, José L. Pablos
Format: Article
Language:English
Published: The Company of Biologists 2021-08-01
Series:Disease Models & Mechanisms
Subjects:
tfam
mitochondrial dysfunction
fibroblasts
inflammation
cellular senescence
Online Access:http://dmm.biologists.org/content/14/8/dmm048995

Internet

http://dmm.biologists.org/content/14/8/dmm048995

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