The in vivo dsRNA Cleavage Has Sequence Preference in Insects

Exogenous dsRNA enters the insect body and can induce the RNAi effect only when it is cleaved into siRNA. However, what kinds of base composition are easier to cut and what kinds of siRNA will be produced in vivo is largely unknown. In this study, we found that dsRNA processing into siRNA has sequen...

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Bibliographic Details
Main Authors: Ruobing Guan, Shaoru Hu, Haichao Li, Zhenying Shi, Xuexia Miao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01768/full