Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress

Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress

Ceramides (Cers), critical for epidermal barrier function, also can inhibit keratinocyte proliferation, while glucosylceramides (GlcCers) exert pro-mitogenic effects. Since alterations in Cer-to-GlcCer ratios appear to modulate cellular growth versus apoptosis, we assessed whether keratinocytes up-r...

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Bibliographic Details
Main Authors: Yoshikazu Uchida, Satoru Murata, Matthias Schmuth, Martin J. Behne, Jeong Deuk Lee, Shinichi Ichikawa, Peter M. Elias, Yoshio Hirabayashi, Walter M. Holleran
Format: Article
Language:English
Published: Elsevier 2002-08-01
Series:Journal of Lipid Research
Subjects:
keratinocytes
apoptosis
cutaneous
sphingomyelin
sphingolipids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520300614

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http://www.sciencedirect.com/science/article/pii/S0022227520300614

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