It takes a village: microbiota, parainflammation, paligenosis and bystander effects in colorectal cancer initiation

It takes a village: microbiota, parainflammation, paligenosis and bystander effects in colorectal cancer initiation

Sporadic colorectal cancer (CRC) is a leading cause of worldwide cancer mortality. It arises from a complex milieu of host and environmental factors, including genetic and epigenetic changes in colon epithelial cells that undergo mutation, selection, clonal expansion, and transformation. The gut mic...

Full description

Bibliographic Details
Main Authors: Xingmin Wang, Ram Babu Undi, Naushad Ali, Mark M. Huycke
Format: Article
Language:English
Published: The Company of Biologists 2021-05-01
Series:Disease Models & Mechanisms
Subjects:
colorectal neoplasms
gut microbiome
radiation-induced bystander effect
neoplastic cell transformation
carcinogenesis
dna damage
cancer stem cells
cell-of-origin
chromosomal instability
mutation
paligenosis
bacteria
cell dedifferentiation
doublecortin-like kinase 1
Online Access:http://dmm.biologists.org/content/14/4/1

Internet

http://dmm.biologists.org/content/14/4/1

Similar Items