Microglial replacement therapy: a potential therapeutic strategy for incurable CSF1R-related leukoencephalopathy

Abstract CSF1R-related leukoencephalopathy is an adult-onset leukoencephalopathy with axonal spheroids and pigmented glia caused by colony stimulating factor 1 receptor (CSF1R) gene mutations. The disease has a global distribution and currently has no cure. Individuals with CSF1R-related leukoenceph...

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Bibliographic Details
Main Authors: Jinming Han, Heela Sarlus, Zbigniew K. Wszolek, Virginija Danylaité Karrenbauer, Robert A. Harris
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Acta Neuropathologica Communications
Subjects:
Online Access:https://doi.org/10.1186/s40478-020-01093-3