MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment

MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment

Matrix metalloproteinase-3 (MMP-3) is known to mediate neuroinflammatory processes by activating microglia, disrupting blood–central nervous system barriers and supporting neutrophil influx into the brain. In addition, the posterior part of the eye, more specifically the retina, the retinal pigment...

Full description

Bibliographic Details
Main Authors: Inge Van Hove, Evy Lefevere, Lies De Groef, Jurgen Sergeys, Manuel Salinas-Navarro, Claude Libert, Roosmarijn Vandenbroucke, Lieve Moons
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
LPS
MMP-3
inflammation
retina
blood–retinal barrier
retinal pigment epithelium
leukostasis
Online Access:http://www.mdpi.com/1422-0067/17/11/1825

Internet

http://www.mdpi.com/1422-0067/17/11/1825

Similar Items