T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer

T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer

The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer cells but are restrained by immunosuppression within the tumor micro-environment (TME). Cancer associated fibroblasts (CAFs) are the dominant stromal cell in the TME and co-localize with T cells in non-small c...

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Bibliographic Details
Main Authors: Richard A O’Connor, Vishwani Chauhan, Layla Mathieson, Helen Titmarsh, Lilian Koppensteiner, Irene Young, Giulia Tagliavini, David A Dorward, Sandrine Prost, Kevin Dhaliwal, William A Wallace, Ahsan R Akram
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
non-small cell lung cancer
cancer-associated fibroblasts
t cells
crosstalk
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1940675

Internet

http://dx.doi.org/10.1080/2162402X.2021.1940675

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