The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

The mechanisms generating epileptic neuronal networks following insults such as severe seizures are unknown. We have previously shown that interfering with the function of the neuron-restrictive silencer factor (NRSF/REST), an important transcription factor that influences neuronal phenotype, attenu...

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Bibliographic Details
Main Authors: Shawn McClelland, Gary P Brennan, Celine Dubé, Seeta Rajpara, Shruti Iyer, Cristina Richichi, Christophe Bernard, Tallie Z Baram
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-08-01
Series:eLife
Subjects:
neuron-restrictive silencing factor
epilepsy
gene set enrichment analysi
Online Access:https://elifesciences.org/articles/01267

Internet

https://elifesciences.org/articles/01267

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